O068 Slow frequency wake EEG and hypoxemia during sleep predicts vigilance performance following extended wakefulness in patients with OSA

Abstract Study Objectives Obstructive sleep apnea is highly prevalent, but heterogeneous making identifying patients at risk of driving impairment challenging. Resting wake electroencephalography (qEEG) associated with vigilance performance in healthy subjects. We examined if qEEG and clinical measures predict OSA. Methods Fifty-four underwent baseline PSG 28hr extended wakefulness (EW) 2 hourly psychomotor test (PVT) Karolinska drowsiness simulator following EW. EEG was subjected to fast Fourier transform analysis derive power delta, theta, alpha beta ranges. Cluster assigned participants into groups either resistant (n=39) or vulnerable (n=15) alertness failure based on PVT performance. Backward stepwise regression models were used determine the strongest clincal predictors impairment. Results Compared patients, group exhibited increased delta (p<0.001) theta (p=0.003) during eyes open across all testing periods. The only significant vulnerability (PVT driving) included O2Nadir from (eyes open) respectively explaining 42 32% variance outcome that Age, BMI, ESS, SOL, TST, AHI, O2 Nadir. Conclusions Slow frequency (delta theta) hypoxemia are predictive future impairments These findings important for fitness drive assessment OSA require validation independent sample.